BindingDB PrimarySearch_ki

Found 365 with Last Name = 'cooper' and Initial = 'aw'

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Glaxosmithkline R&D

Curated by ChEMBL

PNG

BDBM50521218(CHEMBL4434674)

Ki: 0.0794nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by HT...More data for this Ligand-Target Pair

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3D Structure (crystal)

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Glaxosmithkline R&D

Curated by ChEMBL

PNG

BDBM50004529(CHEMBL2216859)

Ki: 0.126nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by HT...More data for this Ligand-Target Pair

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3D Structure (crystal)

Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470598(CHEMBL126050)

Ki: 1nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

PDB Reactome pathway
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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470591(CHEMBL124208)

Ki: 1.30nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

PDB Reactome pathway
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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470590(CHEMBL341357)

Ki: 1.30nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

PDB Reactome pathway
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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470604(CHEMBL338825)

Ki: 1.30nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

PDB Reactome pathway
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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470596(CHEMBL125310)

Ki: 1.60nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

PDB Reactome pathway
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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470583(CHEMBL125696)

Ki: 1.60nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

PDB Reactome pathway
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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470587(CHEMBL124648)

Ki: 2.5nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

PDB Reactome pathway
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Substance-K receptor(GUINEA PIG)
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470591(CHEMBL124208)

Ki: 2.5nMAssay Description:The compound was tested for binding affinity against Tachykinin receptor 2 from guinea pig tracheaMore data for this Ligand-Target Pair

PDB
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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470605(CHEMBL122169)

Ki: 4nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

PDB Reactome pathway
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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470603(CHEMBL124013)

Ki: 4nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470582(CHEMBL126043)

Ki: 5nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

PDB Reactome pathway
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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470599(CHEMBL330766)

Ki: 6.30nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

PDB Reactome pathway
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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470595(CHEMBL122019)

Ki: 6.30nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

PDB Reactome pathway
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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470592(CHEMBL339311)

Ki: 7.90nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

PDB Reactome pathway
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Substance-K receptor(Homo sapiens (Human))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470591(CHEMBL124208)

Ki: 7.90nMAssay Description:The compound was tested for binding affinity against Tachykinin receptor 2 from human expressed in CHO cellsMore data for this Ligand-Target Pair

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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470597(CHEMBL330826)

Ki: 10nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470606(CHEMBL446099)

Ki: 10nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470581(CHEMBL341008)

Ki: 10nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470584(CHEMBL125001)

Ki: 13nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470585(CHEMBL415518)

Ki: 16nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470601(CHEMBL123731)

Ki: 20nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470607(CHEMBL124624)

Ki: 20nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470608(CHEMBL338030)

Ki: 20nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470589(CHEMBL331011)

Ki: 79nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470602(CHEMBL340747)

Ki: 100nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470600(CHEMBL435619)

Ki: 100nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470594(CHEMBL340405)

Ki: 100nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470586(CHEMBL435610)

Ki: 126nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470593(CHEMBL126158)

Ki: 200nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

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Substance-K receptor(Rattus norvegicus (Rat))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470588(CHEMBL340548)

Ki: 1.59E+3nMAssay Description:Binding affinity against tachykinin receptor 2 from rat colon.More data for this Ligand-Target Pair

PDB Reactome pathway
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Substance-P receptor(Homo sapiens (Human))
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470591(CHEMBL124208)

Ki: 7.94E+3nMAssay Description:The compound was tested for binding affinity against Tachykinin receptor 1 from rabbit cortexMore data for this Ligand-Target Pair

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Substance-P receptor(GUINEA PIG)
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470591(CHEMBL124208)

Ki: <1.00E+4nMAssay Description:The compound was tested for binding affinity against Tachykinin receptor 1 from guinea pig tracheaMore data for this Ligand-Target Pair

PDB MMDB
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Neuromedin-K receptor(GUINEA PIG)
Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL

PNG

BDBM50470591(CHEMBL124208)

Ki: 7.94E+4nMAssay Description:The compound was tested for binding affinity against Tachykinin receptor 3 from guinea pig cerebral cortexMore data for this Ligand-Target Pair

PDB
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

PNG

BDBM50413296(CHEMBL473764)

IC50: 0.316nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

PNG

BDBM14774(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)

IC50: 0.398nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

PNG

BDBM50413297(CHEMBL473560)

IC50: 0.398nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

PNG

BDBM50413291(CHEMBL515240)

IC50: 1.58nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

PNG

BDBM50413286(CHEMBL517766)

IC50: 2.51nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

PNG

BDBM50412414(CHEMBL521203)

IC50: 3.16nMAssay Description:Inhibition of human PDE4B in Sf9 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

PNG

BDBM50413298(CHEMBL462150)

IC50: 3.98nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Glaxosmithkline R&D

Curated by ChEMBL

PNG

BDBM50521218(CHEMBL4434674)

IC50: 4nMAssay Description:Inhibition of PI3Kdelta in human PBMC assessed as reduction in cytostim-induced IFNgamma production after 20 hrs by electrochemiluminescence assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Glaxosmithkline R&D

Curated by ChEMBL

PNG

BDBM50536411(CHEMBL4564931)

IC50: 5nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair

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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

PNG

BDBM50413306(CHEMBL515098)

IC50: 5.01nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Glaxosmithkline R&D

Curated by ChEMBL

PNG

BDBM50521215(CHEMBL4435246)

IC50: 6.30nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by HT...More data for this Ligand-Target Pair

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3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

PNG

BDBM50413288(CHEMBL517590)

IC50: 6.31nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Glaxosmithkline R&D

Curated by ChEMBL

PNG

BDBM50536416(CHEMBL4522825)

IC50: 7.90nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair

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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

PNG

BDBM50412405(CHEMBL488634)

IC50: 7.94nMAssay Description:Inhibition of human PDE4B in Sf9 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
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Proto-oncogene tyrosine-protein kinase LCK(Mus musculus)
Gsk

PNG

BDBM26166(2,4-dianilino pyrimidine, 23 | 3-({4-[(5-hydroxy-2...)

IC50: 8.5nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair

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Displayed 1 to 50 (of 365 total ) | Next | Last >>

Filter my 365 hits

Targets 44▿
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B 59
- Proto-oncogene tyrosine-protein kinase LCK 43
- Bromodomain-containing protein 4 32
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 30
- Substance-K receptor 30
- Nuclear receptor subfamily 1 group D member 1 26
- Oxysterols receptor LXR-alpha 25
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 19
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 19
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 19
- Bromodomain adjacent to zinc finger domain protein 2A 13
- Tyrosine-protein kinase Lck 2
- Inhibitor of nuclear factor kappa-B kinase subunit beta 2
- Tyrosine-protein kinase BTK 2
- Substance-P receptor 2
- Inhibitor of nuclear factor kappa-B kinase subunit alpha 2
- Mitogen-activated protein kinase kinase kinase 5 2
- Tyrosine-protein kinase ITK/TSK 2
- Epidermal growth factor receptor 2
- Tyrosine-protein kinase SYK 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta/gamma isoform 2
- Tyrosine-protein kinase JAK3 2
- Tyrosine-protein kinase JAK2 2
- Leucine-rich repeat serine/threonine-protein kinase 2 2
- Rho-associated protein kinase 1 2
- Mitogen-activated protein kinase 14 2
- Aurora kinase B 2
- Glycogen synthase kinase-3 beta 2
- Diacylglycerol kinase zeta 1
- Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 1
- Phosphatidylinositol 4-kinase type 2-alpha 1
- Serine/threonine-protein kinase mTOR 1
- Choline kinase alpha 1
- Mitogen-activated protein kinase 10 1
- DNA-dependent protein kinase catalytic subunit 1
- Sphingosine kinase 1 1
- Potassium voltage-gated channel subfamily H member 2 1
- Neuromedin-K receptor 1
- Choline/ethanolamine kinase 1
- Phosphatidylinositol 4-kinase alpha 1
- Sphingosine kinase 2 1
- Aurora kinase A 1
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 1
- Phosphatidylinositol 4-kinase beta 1
- ...
Publications 8▿
- J Med Chem 61: 11061-11073 (2018) 81
- J Med Chem 59: 7239-51 (2016) 54
- J Med Chem 56: 4729-37 (2013) 51
- J Med Chem 63: 714-746 (2020) 45
- Bioorg Med Chem Lett 17: 4363-8 (2007) 43
- J Med Chem 38: 3772-9 (1995) 33
- Bioorg Med Chem Lett 18: 4237-41 (2008) 31
- Bioorg Med Chem Lett 19: 1380-5 (2009) 27
Institutions 4▿
- Glaxosmithkline R&D 135
- Glaxosmithkline 109
- Gsk 88
- Glaxo Wellcome Medicines Research Centre 33
Affinity: 0.079 to 1.6E+5 nM▿
- Ki 35
- IC50 303
- Kd 1
- EC50 26
- Affinity ≤ nM
Xtal structures: 10
Docked structures: 0
Catalog Cmpds: 10