Reaction Details Report a problem with these data
Target
Substance-K receptor
Ligand
BDBM50470608
Substrate
n/a
Meas. Tech.
ChEMBL_209381 (CHEMBL812073)
Ki
20±n/a nM
Citation
 Smith, PW; Cooper, AW; Bell, R; Beresford, IJ; Gore, PM; McElroy, AB; Pritchard, JM; Saez, V; Taylor, NR; Sheldrick, RL New spiropiperidines as potent and selective non-peptide tachykinin NK2 receptor antagonists. J Med Chem 38:3772-9 (1995) [PubMed]  Article 
Target
Name:
Substance-K receptor
Synonyms:
NK-2 receptor | NK-2R | NK2R_RAT | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | SKR | Substance-K receptor | Tac2r | Tachykinin receptor 2 | Tacr2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43868.63
Organism:
Rattus norvegicus (Rat)
Description:
Neurokinin NK2 TACR2 Murine::P16610
Residue:
390
Sequence:
MGTRAIVSDANILSGLESNATGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAIIAGIWLVALALASPQCFYSTITVDEGATKCVVAWPNDNGGKMLLLYHLVVFVLIYFLPLLVMFGAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVLTFAICWLPYHLYFILGTFQEDIYYHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDRLELTHTPSLSRRVNRCHTKETLFMTGDMTHSEATNGQVGSPQDGEPAGPICKAQA
  
Inhibitor
Name:
BDBM50470608
Synonyms:
CHEMBL338030
Type:
Small organic molecule
Emp. Form.:
C28H28FN3O2
Mol. Mass.:
457.5392
SMILES:
Fc1ccc2[nH]cc(CCN3CCC4(CN(Cc5ccc6ccccc6c5)C(=O)O4)CC3)c2c1
Structure:
Search PDB for entries with ligand similarity: