Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50474535
Substrate
n/a
Meas. Tech.
ChEMBL_140025 (CHEMBL859326)
EC50
14±n/a nM
Citation
 Muth, M; Bender, W; Scharfenstein, O; Holzgrabe, U; Balatkova, E; Tränkle, C; Mohr, K Systematic development of high affinity bis(ammonio)alkane-type allosteric enhancers of muscarinic ligand binding. J Med Chem 46:1031-40 (2003) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_PIG | CHRM2 | Cholinergic, muscarinic | GPM2 | LOC100715343 | Muscarinic acetylcholine receptor M2 | Muscarinic receptor 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51688.65
Organism:
GUINEA PIG
Description:
Cholinergic, muscarinic 0 GUINEA PIG::P06199
Residue:
466
Sequence:
MNNSTNSSNSGLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQEPVSPSLVQGRIVKPNNNNMPGSDEALEHNKIQNGKAPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIKIVTKTQKSDSCTPANTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50474535
Synonyms:
CHEMBL8721
Type:
Small organic molecule
Emp. Form.:
C41H56Br2N4O4
Mol. Mass.:
828.716
SMILES:
[Br-].[Br-].Cc1ccc2C(=O)N(CC(C)(C)C[N+](C)(C)CCCCCC[N+](C)(C)CC(C)(C)CN3C(=O)c4cccc5cccc(C3=O)c45)C(=O)c2c1
Structure:
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