Reaction Details Report a problem with these data
Target
Melatonin receptor type 1B
Ligand
BDBM50011349
Substrate
n/a
Meas. Tech.
ChEMBL_304028 (CHEMBL840206)
Ki
0.660693±n/a nM
Citation
 Lucini, V; Pannacci, M; Scaglione, F; Fraschini, F; Rivara, S; Mor, M; Bordi, F; Plazzi, PV; Spadoni, G; Bedini, A; Piersanti, G; Diamantini, G; Tarzia, G Tricyclic alkylamides as melatonin receptor ligands with antagonist or inverse agonist activity. J Med Chem 47:4202-12 (2004) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1B
Synonyms:
MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2)
Type:
Enzyme
Mol. Mass.:
40203.54
Organism:
Homo sapiens (Human)
Description:
P49286
Residue:
362
Sequence:
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
  
Inhibitor
Name:
BDBM50011349
Synonyms:
CHEMBL189449
Type:
Small organic molecule
Emp. Form.:
C19H21NO2
Mol. Mass.:
295.3755
SMILES:
COc1ccc2Cc3ccccc3CC(CNC(C)=O)c2c1
Structure:
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