Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2B
Ligand
BDBM50476485
Substrate
n/a
Meas. Tech.
ChEMBL_440773 (CHEMBL889870)
Ki
251±n/a nM
Citation
 Hamprecht, D; Micheli, F; Tedesco, G; Checchia, A; Donati, D; Petrone, M; Terreni, S; Wood, M Isoindolone derivatives, a new class of 5-HT2C antagonists: synthesis and biological evaluation. Bioorg Med Chem Lett 17:428-33 (2007) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2B
Synonyms:
5-HT-2B | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] | 5-hydroxytryptamine receptor 2B (5-HT2B) | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2B_HUMAN | HTR2B | Serotonin (5-HT3) receptor | Serotonin 2b (5-HT2b) receptor | Serotonin Receptor 2B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
54312.47
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:
481
Sequence:
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
  
Inhibitor
Name:
BDBM50476485
Synonyms:
CHEMBL234739
Type:
Small organic molecule
Emp. Form.:
C24H26F4N2O3
Mol. Mass.:
466.4685
SMILES:
COc1ccc(cc1OCCN1CCC(C)CC1)N1Cc2cc(F)cc(c2C1=O)C(F)(F)F
Structure:
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