Reaction Details Report a problem with these data
Target
Protein kinase C zeta type
Ligand
BDBM50478518
Substrate
n/a
Meas. Tech.
ChEMBL_546411 (CHEMBL1025810)
IC50
17±n/a nM
Citation
 Erickson, KL; Beutler, JA; Cardellina, JH; McMahon, JB; Newman, DJ; Boyd, MR A novel phorbol ester from Excoecaria agallocha. J Nat Prod 58:769-72 (1995) [PubMed]  Article 
Target
Name:
Protein kinase C zeta type
Synonyms:
KPCZ_RAT | Pkcz | Prkcz | Protein kinase C (PKC) | Protein kinase C zeta type | nPKC-zeta
Type:
PROTEIN
Mol. Mass.:
67722.31
Organism:
Rattus norvegicus
Description:
ChEMBL_104731
Residue:
592
Sequence:
MPSRTDPKMDRSGGRVRLKAHYGGDILITSVDPTTTFQDLCEEVRDMCGLHQQHPLTLKWVDSEGDPCTVSSQMELEEAFRLACQGRDEVLIIHVFPSIPEQPGMPCPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHVLVPLTCRRHMDSVMPSQEPPVDDKNDGVDLPSEETDGIAYISSSRKHDNIKDDSEDLKPVIDGVDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQTLPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDVIKRIDQSEFEGFEYINPLLLSAEESV
  
Inhibitor
Name:
BDBM50478518
Synonyms:
CHEMBL514017
Type:
Small organic molecule
Emp. Form.:
C30H42O6
Mol. Mass.:
498.6509
SMILES:
[H][C@]12[C@]3([H])C=C(CO)C[C@]4(O)C(=O)C(C)=C[C@@]4([H])[C@@]3(O)[C@@H](C)C[C@@]1(OC(=O)C\C=C\C=C\CCCC)C2(C)C |r,c:14,t:4|
Structure:
Search PDB for entries with ligand similarity: