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Target
Cell division protein FtsZ
Ligand
BDBM50079356
Substrate
n/a
Meas. Tech.
ChEMBL_542580 (CHEMBL1014176)
IC50
154±n/a nM
Citation
 Haydon, DJ; Stokes, NR; Ure, R; Galbraith, G; Bennett, JM; Brown, DR; Baker, PJ; Barynin, VV; Rice, DW; Sedelnikova, SE; Heal, JR; Sheridan, JM; Aiwale, ST; Chauhan, PK; Srivastava, A; Taneja, A; Collins, I; Errington, J; Czaplewski, LG An inhibitor of FtsZ with potent and selective anti-staphylococcal activity. Science 321:1673-5 (2008) [PubMed]  Article 
Target
Name:
Cell division protein FtsZ
Synonyms:
FTSZ_STAAU | ftsZ
Type:
Protein
Mol. Mass.:
41023.36
Organism:
Staphylococcus aureus
Description:
P0A031
Residue:
390
Sequence:
MLEFEQGFNHLATLKVIGVGGGGNNAVNRMIDHGMNNVEFIAINTDGQALNLSKAESKIQIGEKLTRGLGAGANPEIGKKAAEESREQIEDAIQGADMVFVTSGMGGGTGTGAAPVVAKIAKEMGALTVGVVTRPFSFEGRKRQTQAAAGVEAMKAAVDTLIVIPNDRLLDIVDKSTPMMEAFKEADNVLRQGVQGISDLIAVSGEVNLDFADVKTIMSNQGSALMGIGVSSGENRAVEAAKKAISSPLLETSIVGAQGVLMNITGGESLSLFEAQEAADIVQDAADEDVNMIFGTVINPELQDEIVVTVIATGFDDKPTSHGRKSGSTGFGTSVNTSSNATSKDESFTSNSSNAQATDSVSERTHTTKEDDIPSFIRNREERRSRRTRR
  
Inhibitor
Name:
BDBM50079356
Synonyms:
CHEMBL511201
Type:
Small organic molecule
Emp. Form.:
C14H8ClF2N3O2S
Mol. Mass.:
355.747
SMILES:
NC(=O)c1c(F)ccc(OCc2nc3cc(Cl)cnc3s2)c1F
Structure:
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