Reaction Details Report a problem with these data
Target
Catechol O-methyltransferase
Ligand
BDBM50012672
Substrate
n/a
Meas. Tech.
ChEBML_47077
Ki
328000±n/a nM
Citation
 Borchardt, RT; Bhatia, P Catechol O-methyltransferase. 12. Affinity labeling the active site with the oxidation products of 5,6-dihydroxyindole. J Med Chem 25:263-71 (1982) [PubMed]  Article 
Target
Name:
Catechol O-methyltransferase
Synonyms:
COMT_RAT | Catechol O-methyltransferase | Catechol-O-methyltransferase | Comt
Type:
Enzyme
Mol. Mass.:
29594.09
Organism:
Rattus norvegicus (Rat)
Description:
n/a
Residue:
264
Sequence:
MPLAAVSLGLLLLALLLLLRHLGWGLVTIFWFEYVLQPVHNLIMGDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEMNPDYAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSSPDKS
  
Inhibitor
Name:
BDBM50012672
Synonyms:
2-(5,6-Dihydroxy-1H-indol-3-yl)-ethyl-ammonium | 2-(5,6-Dihydroxy-1H-indol-3-yl)-ethyl-ammonium(5,6-DHT) | 3-(2-Amino-ethyl)-1H-indole-5,6-diol | CHEMBL303916
Type:
Small organic molecule
Emp. Form.:
C10H12N2O2
Mol. Mass.:
192.2145
SMILES:
NCCc1c[nH]c2cc(O)c(O)cc12
Structure:
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