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Target
C-1-tetrahydrofolate synthase, cytoplasmic
Ligand
BDBM50028981
Substrate
n/a
Meas. Tech.
ChEBML_257
Ki
41000±n/a nM
Citation
 Caperelli, CA; Domanico, P; Benkovic, SJ Synthesis of 5,11-methenyltetrahydrohomofolate and its antifolate activity in vitro. J Med Chem 24:1086-8 (1981) [PubMed]  Article 
Target
Name:
C-1-tetrahydrofolate synthase, cytoplasmic
Synonyms:
C-1-tetrahydrofolate synthase, cytoplasmic | C1-THF synthase | C1TC_HUMAN | Formyltetrahydrofolate synthetase | MTHFC | MTHFD | MTHFD1 | Methenyltetrahydrofolate cyclohydrolase | Methylenetetrahydrofolate dehydrogenase
Type:
PROTEIN
Mol. Mass.:
101566.59
Organism:
Homo sapiens (Human)
Description:
ChEMBL_257
Residue:
935
Sequence:
MAPAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEIGIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKDVDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYVPDDKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLEKFKPGKWMIQYNNLNLKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSALERLKHRPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGIKGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLVPSVNGVRRFSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRFLRKITIGQAPTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPVSAEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVGPEGFVVTEAGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLPKAYIQENLELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTESELDLISRLSREHGAFDAVKCTHWAEGGKGALALAQAVQRAAQAPSSFQLLYDLKLPVEDKIRIIAQKIYGADDIELLPEAQHKAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFILPIRDIRASVGAGFLYPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF
  
Inhibitor
Name:
BDBM50028981
Synonyms:
2-{4-[2-(2-amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl)ethylamino]phenylcarboxamido}-(2S)-pentanedioic acid | CHEMBL12213 | KETOTREXATE
Type:
Small organic molecule
Emp. Form.:
C21H27N7O6
Mol. Mass.:
473.4824
SMILES:
CN1C(CCNc2ccc(cc2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNc2nc(N)[nH]c(=O)c12 |r|
Structure:
Search PDB for entries with ligand similarity: