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Found 107 with Last Name = 'benkovic' and Initial = 'sj'
TargetDihydrofolate reductase(Mus musculus (Mouse))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50130312(4-[12-(4-Carboxy-4-{4-[(2,4-diamino-pteridin-6-ylm...)
Affinity DataKi:  0.0180nMAssay Description:Inhibitory constant of the compound for murine Wild-type dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50130313(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)
Affinity DataKi:  0.0330nMAssay Description:Inhibitory constant of the compound for murine Wild-type dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50011320(CHEMBL18155 | N-(4-Carboxy-4-{4-[(2,4-diamino-pter...)
Affinity DataKi:  0.0420nMAssay Description:Inhibitory constant of the compound for murine Wild-type dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataKi:  0.0600nMAssay Description:Inhibitory constant of the compound for murine Wild-type dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  0.190nMAssay Description:Inhibitor constant of compound for plasmodium falciparum dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  0.190nMAssay Description:Thermodynamic dissociation constant of compound for mutant T46S E. coli dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataKi:  0.810nMAssay Description:Inhibitory constant of the compound for F31A/F34A murine dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  1.20nMAssay Description:Inhibitor constant of compound for mutant S108 N plasmodium falciparum i dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  5.20nMAssay Description:Dissociation rate constant of compound for mutant T46N Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  10nMAssay Description:Dissociation rate constant of compound for mutant T46A Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  20nMAssay Description:Inhibitor constant of compound for mutant T46S E. coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50011320(CHEMBL18155 | N-(4-Carboxy-4-{4-[(2,4-diamino-pter...)
Affinity DataKi:  25.9nMAssay Description:Inhibitory constant of the compound for F31A/F34A murine dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50022831(6,7-Dimethyl-pteridine-2,4-diamine | CHEMBL29143)
Affinity DataKi:  44nMAssay Description:Thermodynamic Dissociation Constant for compound-Tyr31-dihydrofolate reductase (DHFR) complex at pH 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50022831(6,7-Dimethyl-pteridine-2,4-diamine | CHEMBL29143)
Affinity DataKi:  57nMAssay Description:Inhibition constant for Tyr31-dihydrofolate reductase (DHFR)-NADPH-Compound complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mus musculus)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50367875(CHEMBL607957)
Affinity DataKi: >100nMAssay Description:Compound was tested for inhibition constant against GAR TFase in miceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine-4-hydroxylase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50028430(2-Amino-6-phenyl-7,8-dihydro-3H,6H-pyrimido[5,4-b]...)
Affinity DataKi:  200nMAssay Description:Tested for competitive binding inhibition against phenylalanine hydroxylase in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50130312(4-[12-(4-Carboxy-4-{4-[(2,4-diamino-pteridin-6-ylm...)
Affinity DataKi:  212nMAssay Description:Inhibitory constant of the compound for F31A/F34A murine dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  330nMAssay Description:Thermodynamic Dissociation Constant for compound-Tyr31-dihydrofolate reductase (DHFR) complex at pH 9.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50130313(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)
Affinity DataKi:  333nMAssay Description:Inhibitory constant of the compound for F31A/F34A murine dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
University of Southampton

LigandPNGBDBM92374(RY Analogue, 14)
Affinity DataKi:  685nM ΔG°:  -35.2kJ/moleT: 2°CAssay Description:Enzyme inhibition using aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Saccharomyces cerevisiae S288c)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50370987(TAVABOROLE)
Affinity DataKi:  1.85E+3nMAssay Description:Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  2.40E+3nM ΔG°:  -32.1kJ/molepH: 5.5 T: 2°CAssay Description:Thermodynamic Dissociation Constant for compound-Val31-dihydrofolate reductase (DHFR) complex at pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
University of Southampton

LigandPNGBDBM92376(RY Analogue, 17)
Affinity DataKi:  2.50E+3nM ΔG°:  -32.0kJ/moleT: 2°CAssay Description:Enzyme inhibition using aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine-4-hydroxylase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50028428(2,6-Diamino-5-phenylsulfanyl-3H-pyrimidin-4-one | ...)
Affinity DataKi:  4.70E+3nMAssay Description:Tested for competitive binding inhibition against phenylalanine hydroxylase in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine-4-hydroxylase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50028426(2-Amino-5-oxo-6-phenyl-5,6,7,8-tetrahydro-3H-5lamb...)
Affinity DataKi:  7.00E+3nMAssay Description:Tested for competitive binding inhibition against phenylalanine hydroxylase in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM50022831(6,7-Dimethyl-pteridine-2,4-diamine | CHEMBL29143)
Affinity DataKi:  9.10E+3nMAssay Description:Dissociation constant at(Koff) Tyr-31 of dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
University of Southampton

LigandPNGBDBM50089572(2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylme...)
Affinity DataKi:  1.70E+4nMAssay Description:In vitro inhibitory activity against Aminoimidazole carboxamide ribonucleotide transformylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Saccharomyces cerevisiae S288c)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50370987(TAVABOROLE)
Affinity DataKi:  3.14E+4nMAssay Description:Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase after 2 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50089585(2,6-Diamino-5-[2-(4,5-difluoro-2-nitro-phenylamino...)
Affinity DataKi:  3.50E+4nMAssay Description:In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase) after 3 min at 250 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine-4-hydroxylase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50028425(2-Amino-6-methyl-7,8-dihydro-3H,6H-pyrimido[5,4-b]...)
Affinity DataKi:  3.60E+4nMAssay Description:Tested for competitive binding inhibition against phenylalanine hydroxylase in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-1-tetrahydrofolate synthase, cytoplasmic(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50028981(2-{4-[2-(2-amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahy...)
Affinity DataKi:  4.10E+4nMAssay Description:Compound was tested for in vitro inhibition of 5,10-Methylene Tetrahydrofolate Cyclohydrolase ,competitive against (+)-L-5,10-methenyltetrahydrofolat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50089594(2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylme...)
Affinity DataKi:  4.50E+4nMAssay Description:In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
University of Southampton

LigandPNGBDBM50089594(2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylme...)
Affinity DataKi:  5.20E+4nMAssay Description:In vitro inhibitory activity against Aminoimidazole carboxamide ribonucleotide transformylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
University of Southampton

LigandPNGBDBM92372(RY Analogue, 12)
Affinity DataKi:  5.60E+4nM ΔG°:  -24.3kJ/moleT: 2°CAssay Description:Enzyme inhibition using aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
University of Southampton

LigandPNGBDBM92373(RY Analogue, 13)
Affinity DataKi:  5.90E+4nM ΔG°:  -24.1kJ/moleT: 2°CAssay Description:Enzyme inhibition using aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
University of Southampton

LigandPNGBDBM92368(RY Analogue, 8)
Affinity DataKi:  8.40E+4nM ΔG°:  -23.3kJ/moleT: 2°CAssay Description:Enzyme inhibition using aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine-4-hydroxylase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50028424(2-Amino-7,8-dihydro-3H,6H-pyrimido[5,4-b][1,4]thia...)
Affinity DataKi:  8.50E+4nMAssay Description:Tested for competitive binding inhibition against phenylalanine hydroxylase in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
University of Southampton

LigandPNGBDBM92371(RY Analogue, 11)
Affinity DataKi:  8.70E+4nM ΔG°:  -23.2kJ/moleT: 2°CAssay Description:Enzyme inhibition using aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50089572(2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylme...)
Affinity DataKi: >1.00E+5nMAssay Description:In vitro inhibitory activity against Glycinamide ribonucleotide transformylase (GAR Tfase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine-4-hydroxylase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50028427(2-Amino-6-methyl-5-oxo-5,6,7,8-tetrahydro-3H-5lamb...)
Affinity DataKi:  1.25E+5nMAssay Description:Tested for competitive binding inhibition against phenylalanine hydroxylase in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
University of Southampton

LigandPNGBDBM92370(RY Analogue, 10)
Affinity DataKi:  1.35E+5nM ΔG°:  -22.1kJ/moleT: 2°CAssay Description:Enzyme inhibition using aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
University of Southampton

LigandPNGBDBM92375(RY Analogue, 16)
Affinity DataKi:  1.45E+5nM ΔG°:  -21.9kJ/moleT: 2°CAssay Description:Enzyme inhibition using aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Pennsylvania State University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  1.70E+5nMAssay Description:Thermodynamic Dissociation Constant for compound-Phe31-dihydrofolate reductase (DHFR) complex at pH 8.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
University of Southampton

LigandPNGBDBM92369(RY Analogue, 9)
Affinity DataKi:  3.39E+5nM ΔG°:  -19.8kJ/moleT: 2°CAssay Description:Enzyme inhibition using aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine-4-hydroxylase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50028431(2-Amino-5-oxo-5,6,7,8-tetrahydro-3H-5lambda*4*-pyr...)
Affinity DataKi:  4.00E+5nMAssay Description:Tested for competitive binding inhibition against phenylalanine hydroxylase in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylalanine-4-hydroxylase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50028429(2-Amino-3,5,6,7-tetrahydro-pyrimido[4,5-b][1,4]thi...)
Affinity DataKi:  5.00E+5nMAssay Description:Tested for competitive binding inhibition against phenylalanine hydroxylase in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
University of Southampton

LigandPNGBDBM50369444(CHEMBL608337)
Affinity DataIC50:  125nMAssay Description:Inhibitory activity against AICAR formyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Saccharomyces cerevisiae S288c)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50370987(TAVABOROLE)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase assessed as tRNA amino-acylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
University of Southampton

LigandPNGBDBM50080319(10-Formyl-8-deazafolic acid | CHEMBL114215)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibitory activity against AICAR formyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
University of Southampton

LigandPNGBDBM22579(AICAR | Aminoimidazole-4-carboxamide ribonucleotid...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibitory activity against AICAR formyltransferaseMore data for this Ligand-Target Pair
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