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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50485920
Substrate
n/a
Meas. Tech.
ChEMBL_877418 (CHEMBL2182848)
IC50
1940±n/a nM
Citation
 Sartini, S; Cosconati, S; Marinelli, L; Barresi, E; Di Maro, S; Simorini, F; Taliani, S; Salerno, S; Marini, AM; Da Settimo, F; Novellino, E; La Motta, C Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular modeling studies. J Med Chem 55:10523-31 (2012) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50485920
Synonyms:
CHEMBL2180649
Type:
Small organic molecule
Emp. Form.:
C14H9F3N2O3
Mol. Mass.:
310.2281
SMILES:
[O-][n+]1onc2cc(OCc3ccc(cc3)C(F)(F)F)ccc12
Structure:
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