Reaction Details Report a problem with these data
Target
Tumor necrosis factor receptor superfamily member 16
Ligand
BDBM50029497
Substrate
n/a
Meas. Tech.
ChEMBL_144433 (CHEMBL753643)
IC50
1300±n/a nM
Citation
 Jaen, JC; Laborde, E; Bucsh, RA; Caprathe, BW; Sorenson, RJ; Fergus, J; Spiegel, K; Marks, J; Dickerson, MR; Davis, RE Kynurenic acid derivatives inhibit the binding of nerve growth factor (NGF) to the low-affinity p75 NGF receptor. J Med Chem 38:4439-45 (1995) [PubMed]  Article 
Target
Name:
Tumor necrosis factor receptor superfamily member 16
Synonyms:
CD_antigen=CD271 | Gp80-LNGFR | Low affinity neurotrophin receptor p75NTR | Low-affinity nerve growth factor receptor | NGF receptor | NGFR | TNFRSF16 | TNR16_HUMAN | Tumor necrosis factor receptor superfamily member 16 | p75 ICD
Type:
PROTEIN
Mol. Mass.:
45159.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_346884
Residue:
427
Sequence:
MGAGATGRAMDGPRLLLLLLLGVSLGGAKEACPTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQPVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSSLPPAKREEVEKLLNGSAGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSESTATSPV
  
Inhibitor
Name:
BDBM50029497
Synonyms:
2-Methyl-7-oxo-5-(tetrazol-1-ylcarbamoyl)-4,7-dihydro-thieno[3,2-b]pyridine-3-carboxylic acid methyl ester | CHEMBL136617
Type:
Small organic molecule
Emp. Form.:
C12H10N6O4S
Mol. Mass.:
334.311
SMILES:
COC(=O)c1c(C)sc2c(O)cc(nc12)C(=O)Nn1cnnn1
Structure:
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