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Target
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Ligand
BDBM8726
Substrate
n/a
Meas. Tech.
ChEMBL_963434 (CHEMBL2389279)
IC50
5.0±n/a nM
Citation
 Lauinger, IL; Vivas, L; Perozzo, R; Stairiker, C; Tarun, A; Zloh, M; Zhang, X; Xu, H; Tonge, PJ; Franzblau, SG; Pham, DH; Esguerra, CV; Crawford, AD; Maes, L; Tasdemir, D Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target. J Nat Prod 76:1064-70 (2013) [PubMed]  Article 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
Synonyms:
Enoyl - (acyl carrier protein) reductase | Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-acyl carrier protein reductase (FabI) | FABI_ECOLI | NADH-dependent enoyl-ACP reductase | envM | fabI
Type:
Enzyme
Mol. Mass.:
27861.12
Organism:
Escherichia coli
Description:
n/a
Residue:
262
Sequence:
MGFLSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGRVEEFAAQLGSDIVLQCDVAEDASIDTMFAELGKVWPKFDGFVHSIGFAPGDQLDGDYVNAVTREGFKIAHDISSYSFVAMAKACRSMLNPGSALLTLSYLGAERAIPNYNVMGLAKASLEANVRYMANAMGPEGVRVNAISAGPIRTLAASGIKDFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSDLSAGISGEVVHVDGGFSIAAMNELELK
  
Inhibitor
Name:
BDBM8726
Synonyms:
5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849 | TCL | Triclosan | US20230414581, Compound 35
Type:
Small organic molecule
Emp. Form.:
C12H7Cl3O2
Mol. Mass.:
289.542
SMILES:
Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl
Structure:
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