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Target
NADPH oxidase 5
Ligand
BDBM50497269
Substrate
n/a
Meas. Tech.
ChEMBL_1390862 (CHEMBL3391330)
IC50
>100000±n/a nM
Citation
 Cifuentes-Pagano, E; Saha, J; Csányi, G; Ghouleh, IA; Sahoo, S; Rodríguez, A; Wipf, P; Pagano, PJ; Skoda, EM Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors. Medchemcomm 4:1085-1092 (2013) [PubMed]  Article 
Target
Name:
NADPH oxidase 5
Synonyms:
NOX5 | NOX5_HUMAN
Type:
PROTEIN
Mol. Mass.:
86463.60
Organism:
Homo sapiens (Human)
Description:
ChEMBL_792880
Residue:
765
Sequence:
MNTSGDPAQTGPEGCRGTMSAEEDARWLRWVTQQFKTIAGEDGEISLQEFKAALHVKESFFAERFFALFDSDRSGTITLQELQEALTLLIHGSPMDKLKFLFQVYDIDVCARQGASAGTEWGAGAGPHWASSPLGTGSGSIDPDELRTVLQSCLRESAISLPDEKLDQLTLALFESADADGNGAITFEELRDELQRFPGVMENLTISAAHWLTAPAPRPRPRRPRQLTRAYWHNHRSQLFCLATYAGLHVLLFGLAASAHRDLGASVMVAKGCGQCLNFDCSFIAVLMLRRCLTWLRATWLAQVLPLDQNIQFHQLMGYVVVGLSLVHTVAHTVNFVLQAQAEASPFQFWELLLTTRPGIGWVHGSASPTGVALLLLLLLMFICSSSCIRRSGHFEVFYWTHLSYLLVWLLLIFHGPNFWKWLLVPGILFFLEKAIGLAVSRMAAVCIMEVNLLPSKVTHLLIKRPPFFHYRPGDYLYLNIPTIARYEWHPFTISSAPEQKDTIWLHIRSQGQWTNRLYESFKASDPLGRGSKRLSRSVTMRKSQRSSKGSEILLEKHKFCNIKCYIDGPYGTPTRRIFASEHAVLIGAGIGITPFASILQSIMYRHQKRKHTCPSCQHSWIEGVQDNMKLHKVDFIWINRDQRSFEWFVSLLTKLEMDQAEEAQYGRFLELHMYMTSALGKNDMKAIGLQMALDLLANKEKKDSITGLQTRTQPGRPDWSKVFQKVAAEKKGKVQVFFCGSPALAKVLKGHCEKFGFRFFQENF
  
Inhibitor
Name:
BDBM50497269
Synonyms:
CHEMBL3347584
Type:
Small organic molecule
Emp. Form.:
C23H25BrFNO2S
Mol. Mass.:
478.418
SMILES:
[H][C@@]12CC(C)(C)[C@@]([H])([C@H](CC(C)=C)N1S(=O)(=O)c1ccc(F)cc1)c1c(Br)cccc21 |r,TLB:9:8:3.2:30.24,25:24:3.2:13.8,THB:14:13:3.2:30.24|
Structure:
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