Reaction Details Report a problem with these data
Target
Elastase
Ligand
BDBM50497677
Substrate
n/a
Meas. Tech.
ChEMBL_1442820 (CHEMBL3376525)
IC50
20000±n/a nM
Citation
 Adekoya, OA; Sjøli, S; Wuxiuer, Y; Bilto, I; Marques, SM; Santos, MA; Nuti, E; Cercignani, G; Rossello, A; Winberg, JO; Sylte, I Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors. Eur J Med Chem 89:340-8 (2015) [PubMed]  Article 
Target
Name:
Elastase
Synonyms:
ELAS_PSEAE | Pseudolysin | lasB
Type:
PROTEIN
Mol. Mass.:
53687.94
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_619859
Residue:
498
Sequence:
MKKVSTLDLLFVAIMGVSPAAFAADLIDVSKLPSKAAQGAPGPVTLQAAVGAGGADELKAIRSTTLPNGKQVTRYEQFHNGVRVVGEAITEVKGPGKSVAAQRSGHFVANIAADLPGSTTAAVSAEQVLAQAKSLKAQGRKTENDKVELVIRLGENNIAQLVYNVSYLIPGEGLSRPHFVIDAKTGEVLDQWEGLAHAEAGGPGGNQKIGKYTYGSDYGPLIVNDRCEMDDGNVITVDMNSSTDDSKTTPFRFACPTNTYKQVNGAYSPLNDAHFFGGVVFKLYRDWFGTSPLTHKLYMKVHYGRSVENAYWDGTAMLFGDGATMFYPLVSLDVAAHEVSHGFTEQNSGLIYRGQSGGMNEAFSDMAGEAAEFYMRGKNDFLIGYDIKKGSGALRYMDQPSRDGRSIDNASQYYNGIDVHHSSGVYNRAFYLLANSPGWDTRKAFEVFVDANRYYWTATSNYNSGACGVIRSAQNRNYSAADVTRAFSTVGVTCPSAL
  
Inhibitor
Name:
BDBM50497677
Synonyms:
CHEMBL3361129
Type:
Small organic molecule
Emp. Form.:
C11H13N3O6
Mol. Mass.:
283.2374
SMILES:
ONC(=O)CN(CC(O)=O)Cc1ccc(cc1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: