Compile Data Set for Download or QSAR
maximum 50k data
Found 46 with Last Name = 'wuxiuer' and Initial = 'y'
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321113(3-Phenyl-2-(trifluoromethyl)quinazolin-4(3H)-one |...)
Affinity DataKi:  11.5nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321123(3-(Isopropylideneamino)-2,2-dimethyl-2,3-dihydroqu...)
Affinity DataKi:  243nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321122(2-Ethylquinazolin-4(3H)-one | CHEMBL1163173)
Affinity DataKi:  1.25E+3nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321112(3-Amino-2-(trifluoromethyl)quinazolin-4(3H)-one | ...)
Affinity DataKi:  3.79E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321118(3-({(1E)-[4-(Dimethylamino)phenyl]methylene}amino)...)
Affinity DataKi:  4.20E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321114(3-Amino-2-methylquinazolin-4(3H)-one | CHEMBL11631...)
Affinity DataKi:  5.49E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321115(2-(4-Methylphenyl)-3-(1,3-thiazol-2-yl)quinazolin-...)
Affinity DataKi:  5.93E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321119(3-({(1E)-[4-(Dimethylamino)phenyl]methylene}amino)...)
Affinity DataKi:  1.83E+6nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321116(3-Amino-2-(4-nitrophenyl)quinazolin-4(3H)-one | CH...)
Affinity DataKi:  3.12E+6nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321120(3-{[(1E)-(3-Chlorophenyl)methylene]amino}-2-phenyl...)
Affinity DataKi:  4.00E+6nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321117(3-Amino-2-(4-chlorophenyl)quinazolin-4(3H)-one | C...)
Affinity DataKi:  1.01E+7nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321121(CHEMBL1163684 | EthanimidicacidN-[4-oxo-2-phenyl-3...)
Affinity DataKi:  1.06E+8nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321113(3-Phenyl-2-(trifluoromethyl)quinazolin-4(3H)-one |...)
Affinity DataIC50:  11.5nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321123(3-(Isopropylideneamino)-2,2-dimethyl-2,3-dihydroqu...)
Affinity DataIC50:  248nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50241254(2-(benzyl-hydroxycarbamoylmethyl-amino)-N-[2-(4-su...)
Affinity DataIC50:  400nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide as substrate after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321122(2-Ethylquinazolin-4(3H)-one | CHEMBL1163173)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50497676(CHEMBL3361134)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(Dnp)-OH as substrate after 1 hr by fluorescence assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50497676(CHEMBL3361134)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide as substrate after 15 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50241251(2-[hydroxycarbamoylmethyl-(4-methoxy-benzenesulfon...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide as substrate after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50241252(2-[hydroxycarbamoylmethyl-(4-phenoxy-benzenesulfon...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide as substrate after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50497677(CHEMBL3361129)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide as substrate after 15 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50241253(2-[(biphenyl-4-sulfonyl)-hydroxycarbamoylmethyl-am...)
Affinity DataIC50:  3.10E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide as substrate after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50241251(2-[hydroxycarbamoylmethyl-(4-methoxy-benzenesulfon...)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(Dnp)-OH as substrate after 1 hr by fluorescence assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321112(3-Amino-2-(trifluoromethyl)quinazolin-4(3H)-one | ...)
Affinity DataIC50:  3.79E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321118(3-({(1E)-[4-(Dimethylamino)phenyl]methylene}amino)...)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50246601(2-(N-(2-(hydroxyamino)-2-oxoethyl)-4-phenoxyphenyl...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(Dnp)-OH as substrate after 1 hr by fluorescence assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321114(3-Amino-2-methylquinazolin-4(3H)-one | CHEMBL11631...)
Affinity DataIC50:  5.49E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321115(2-(4-Methylphenyl)-3-(1,3-thiazol-2-yl)quinazolin-...)
Affinity DataIC50:  7.69E+4nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50273426(CHEMBL515980 | N-(4-Phenoxybenzenesulfonyl)-N-hydr...)
Affinity DataIC50:  8.20E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide as substrate after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50497678(CHEMBL3361130)
Affinity DataIC50: >1.21E+5nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide as substrate after 15 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321121(CHEMBL1163684 | EthanimidicacidN-[4-oxo-2-phenyl-3...)
Affinity DataIC50:  1.23E+5nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50497679(CHEMBL3361132)
Affinity DataIC50: >1.50E+5nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide as substrate after 15 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50246600(2-(N-(2-(hydroxyamino)-2-oxoethyl)-4-methoxyphenyl...)
Affinity DataIC50:  1.53E+5nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(Dnp)-OH as substrate after 1 hr by fluorescence assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50246600(2-(N-(2-(hydroxyamino)-2-oxoethyl)-4-methoxyphenyl...)
Affinity DataIC50:  1.69E+5nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide as substrate after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50246601(2-(N-(2-(hydroxyamino)-2-oxoethyl)-4-phenoxyphenyl...)
Affinity DataIC50: >1.86E+5nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide as substrate after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50497675(CHEMBL3361131)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide as substrate after 15 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50497679(CHEMBL3361132)
Affinity DataIC50:  2.41E+5nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(Dnp)-OH as substrate after 1 hr by fluorescence assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50241252(2-[hydroxycarbamoylmethyl-(4-phenoxy-benzenesulfon...)
Affinity DataIC50:  2.76E+5nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(Dnp)-OH as substrate after 1 hr by fluorescence assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50497674(CHEMBL234528)
Affinity DataIC50: >2.82E+5nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide as substrate after 15 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50497680(CHEMBL3361133)
Affinity DataIC50: >3.30E+5nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide as substrate after 15 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50273426(CHEMBL515980 | N-(4-Phenoxybenzenesulfonyl)-N-hydr...)
Affinity DataIC50:  3.36E+5nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(Dnp)-OH as substrate after 1 hr by fluorescence assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50497675(CHEMBL3361131)
Affinity DataIC50:  4.30E+5nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(Dnp)-OH as substrate after 1 hr by fluorescence assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321119(3-({(1E)-[4-(Dimethylamino)phenyl]methylene}amino)...)
Affinity DataIC50:  1.83E+6nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321116(3-Amino-2-(4-nitrophenyl)quinazolin-4(3H)-one | CH...)
Affinity DataIC50:  3.12E+6nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321120(3-{[(1E)-(3-Chlorophenyl)methylene]amino}-2-phenyl...)
Affinity DataIC50:  4.00E+6nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50321117(3-Amino-2-(4-chlorophenyl)quinazolin-4(3H)-one | C...)
Affinity DataIC50:  1.27E+7nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed