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Target
Retinoic acid receptor RXR-alpha
Ligand
BDBM50497864
Substrate
n/a
Meas. Tech.
ChEMBL_1456698 (CHEMBL3370754)
Kd
488±n/a nM
Citation
 Chen, F; Liu, J; Huang, M; Hu, M; Su, Y; Zhang, XK Identification of a New RXR? Antagonist Targeting the Coregulator-Binding Site. ACS Med Chem Lett 5:736-741 (2014) [PubMed]  Article 
Target
Name:
Retinoic acid receptor RXR-alpha
Synonyms:
NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50820.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456363
Residue:
462
Sequence:
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
  
Inhibitor
Name:
BDBM50497864
Synonyms:
CHEMBL3319093
Type:
Small organic molecule
Emp. Form.:
C20H15N3O4S2
Mol. Mass.:
425.481
SMILES:
Cc1cc(=O)oc2c(\C=N\NC(=O)CSc3nc4ccccc4s3)c(O)ccc12
Structure:
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