Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 2
Ligand
BDBM50504109
Substrate
n/a
Meas. Tech.
ChEMBL_1813494 (CHEMBL4313068)
IC50
8.0±n/a nM
Citation
 Wang, Y; Dai, Y; Wu, X; Li, F; Liu, B; Li, C; Liu, Q; Zhou, Y; Wang, B; Zhu, M; Cui, R; Tan, X; Xiong, Z; Liu, J; Tan, M; Xu, Y; Geng, M; Jiang, H; Liu, H; Ai, J; Zheng, M Discovery and Development of a Series of Pyrazolo[3,4- J Med Chem 62:7473-7488 (2019) [PubMed]  Article 
Target
Name:
Fibroblast growth factor receptor 2
Synonyms:
BEK | CD_antigen=CD332 | FGFR-2 | FGFR-2 Tyrosine Kinase | FGFR2 | FGFR2_HUMAN | Fibroblast growth factor receptor 2 (FGFR2) | Fibroblast growth factor receptor 2 precursor | KGFR | KSAM | Keratinocyte growth factor receptor | Keratinocyte growth factor receptor 2 | VEGF-receptor 2 and Fibroblast growth factor receptor 2
Type:
Enzyme
Mol. Mass.:
92015.45
Organism:
Homo sapiens (Human)
Description:
P21802
Residue:
821
Sequence:
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
  
Inhibitor
Name:
BDBM50504109
Synonyms:
CHEMBL4447110
Type:
Small organic molecule
Emp. Form.:
C29H29N7O4
Mol. Mass.:
539.5851
SMILES:
Cc1c(oc2ccc(C)cc12)-c1n(nc2c1c(N)n[nH]c2=O)-c1ccc(NC(=O)\C=C\CN2CCOCC2)cc1 |(58.33,-22.33,;57.08,-21.43,;55.62,-21.91,;54.71,-20.67,;55.6,-19.42,;55.28,-17.93,;56.41,-16.89,;57.88,-17.36,;59.02,-16.32,;58.2,-18.86,;57.07,-19.89,;55.15,-23.37,;56.06,-24.61,;55.16,-25.86,;53.7,-25.39,;53.69,-23.86,;52.36,-23.08,;52.36,-21.54,;51.03,-23.86,;51.03,-25.4,;52.36,-26.16,;52.36,-27.7,;57.59,-24.6,;58.37,-25.93,;59.91,-25.92,;60.67,-24.58,;62.21,-24.57,;62.99,-25.9,;62.23,-27.24,;64.53,-25.89,;65.31,-27.22,;66.85,-27.21,;67.63,-28.54,;66.86,-29.87,;67.64,-31.19,;69.18,-31.19,;69.94,-29.85,;69.17,-28.51,;59.89,-23.25,;58.35,-23.26,)|
Structure:
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