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Target
Delta-type opioid receptor
Ligand
BDBM50506108
Substrate
n/a
Meas. Tech.
ChEMBL_1824926 (CHEMBL4324690)
Ki
134±n/a nM
Citation
 Xiao, L; Wang, Y; Zhang, M; Wu, W; Kong, L; Ma, Y; Xu, X; Liu, X; He, Q; Qian, Y; Sun, H; Wu, H; Lin, C; Huang, H; Ye, R; Jiang, S; Ye, RF; Yuan, C; Fang, S; Xue, D; Yang, X; Chen, H; Zheng, Y; Yu, L; Xie, Q; Zheng, L; Fu, W; Li, W; Qiu, Z; Liu, J; Shao, L Discovery of a Highly Selective and Potent ? Opioid Receptor Agonist from  J Med Chem 62:11054-11070 (2019) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | OPRD_RAT | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Opioid receptors; mu & delta | Oprd1 | Ror-a | Voltage-gated potassium channel
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40465.04
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor.
Residue:
372
Sequence:
MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50506108
Synonyms:
CHEMBL4449252
Type:
Small organic molecule
Emp. Form.:
C37H40N2O4
Mol. Mass.:
576.7245
SMILES:
[H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]51CC[C@@]2(OC)[C@H](C1)c1ccc(NC(=O)c2ccccc2)cc1)ccc3OC |r,THB:10:9:17:4.5.6|
Structure:
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