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Target
Probable G-protein coupled receptor 88
Ligand
BDBM50506609
Substrate
n/a
Meas. Tech.
ChEMBL_1826484 (CHEMBL4326358)
EC50
63±n/a nM
Citation
 Jin, C; Decker, AM; Makhijani, VH; Besheer, J; Darcq, E; Kieffer, BL; Maitra, R Discovery of a Potent, Selective, and Brain-Penetrant Small Molecule that Activates the Orphan Receptor GPR88 and Reduces Alcohol Intake. J Med Chem 61:6748-6758 (2018) [PubMed]  Article 
Target
Name:
Probable G-protein coupled receptor 88
Synonyms:
GPR88 | GPR88_HUMAN | Probable G-protein coupled receptor 88 | STRG | Striatum-specific G-protein coupled receptor
Type:
PROTEIN
Mol. Mass.:
40264.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109566
Residue:
384
Sequence:
MTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
  
Inhibitor
Name:
BDBM50506609
Synonyms:
CHEMBL4583504
Type:
Small organic molecule
Emp. Form.:
C29H37Cl2N3O2
Mol. Mass.:
530.529
SMILES:
Cl.Cl.CCCc1ccc(cc1)-c1ccc(cc1)N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]1C[C@H]1c1ccccn1 |r|
Structure:
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