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Target
Casein kinase I isoform epsilon
Ligand
BDBM50364141
Substrate
n/a
Meas. Tech.
ChEMBL_1836637 (CHEMBL4336770)
IC50
80±n/a nM
Citation
 Qiao, Y; Chen, T; Yang, H; Chen, Y; Lin, H; Qu, W; Feng, F; Liu, W; Guo, Q; Liu, Z; Sun, H Small molecule modulators targeting protein kinase CK1 and CK2. Eur J Med Chem 181:0 (2019) [PubMed]  Article 
Target
Name:
Casein kinase I isoform epsilon
Synonyms:
Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Ɛ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN
Type:
Protein
Mol. Mass.:
47340.25
Organism:
Homo sapiens (Human)
Description:
P49674
Residue:
416
Sequence:
MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAGNTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
  
Inhibitor
Name:
BDBM50364141
Synonyms:
CHEMBL1951415
Type:
Small organic molecule
Emp. Form.:
C19H20FN5
Mol. Mass.:
337.394
SMILES:
Nc1nccc(n1)-c1c(ncn1C1CCCCC1)-c1ccc(F)cc1
Structure:
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