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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM50510151
Substrate
n/a
Meas. Tech.
ChEMBL_1840502 (CHEMBL4340801)
IC50
>2000±n/a nM
Citation
 Shi, XL; Wu, JD; Liu, P; Liu, ZP Synthesis and evaluation of novel GSK-3? inhibitors as multifunctional agents against Alzheimer's disease. Eur J Med Chem 167:211-225 (2019) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM50510151
Synonyms:
CHEMBL4453426
Type:
Small organic molecule
Emp. Form.:
C21H18ClN5O
Mol. Mass.:
391.854
SMILES:
Nc1nccc(-c2ccc(Cl)cc2)c1\N=C\c1ccnc(NC(=O)C2CC2)c1
Structure:
Search PDB for entries with ligand similarity: