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Target
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
Ligand
BDBM50514011
Substrate
n/a
Meas. Tech.
ChEMBL_1855345 (CHEMBL4356074)
IC50
9500±n/a nM
Citation
 Huryn, DM; Kornfilt, DJP; Wipf, P p97: An Emerging Target for Cancer, Neurodegenerative Diseases, and Viral Infections. J Med Chem 63:1892-1907 (2020) [PubMed]  Article 
Target
Name:
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
Synonyms:
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial | CLPX | CLPX_HUMAN
Type:
PROTEIN
Mol. Mass.:
69229.49
Organism:
Homo sapiens
Description:
ChEMBL_116782
Residue:
633
Sequence:
MPSCGACTCGAAAVRLITSSLASAQRGISGGRIHMSVLGRLGTFETQILQRAPLRSFTETPAYFASKDGISKDGSGDGNKKSASEGSSKKSGSGNSGKGGNQLRCPKCGDLCTHVETFVSSTRFVKCEKCHHFFVVLSEADSKKSIIKEPESAAEAVKLAFQQKPPPPPKKIYNYLDKYVVGQSFAKKVLSVAVYNHYKRIYNNIPANLRQQAEVEKQTSLTPRELEIRRREDEYRFTKLLQIAGISPHGNALGASMQQQVNQQIPQEKRGGEVLDSSHDDIKLEKSNILLLGPTGSGKTLLAQTLAKCLDVPFAICDCTTLTQAGYVGEDIESVIAKLLQDANYNVEKAQQGIVFLDEVDKIGSVPGIHQLRDVGGEGVQQGLLKLLEGTIVNVPEKNSRKLRGETVQVDTTNILFVASGAFNGLDRIISRRKNEKYLGFGTPSNLGKGRRAAAAADLANRSGESNTHQDIEEKDRLLRHVEARDLIEFGMIPEFVGRLPVVVPLHSLDEKTLVQILTEPRNAVIPQYQALFSMDKCELNVTEDALKAIARLALERKTGARGLRSIMEKLLLEPMFEVPNSDIVCVEVDKEVVEGKKEPGYIRAPTKESSEEEYDSGVEEEGWPRQADAANS
  
Inhibitor
Name:
BDBM50514011
Synonyms:
CHEMBL2047407
Type:
Small organic molecule
Emp. Form.:
C30H40O7
Mol. Mass.:
512.6344
SMILES:
[H][C@@]12C[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)[C@@]5([H])CC(C)=C(COC(C)=O)C(=O)O5)[C@@]4(C)CC[C@]3([H])[C@@]3(C)C(=O)C=C[C@H](O)[C@@]13O2 |r,c:40,t:17|
Structure:
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