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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50518505
Substrate
n/a
Meas. Tech.
ChEMBL_1871835 (CHEMBL4373002)
IC50
4.40±n/a nM
Citation
 Barberis, C; Pribish, J; Tserlin, E; Gross, A; Czekaj, M; Barragué, M; Erdman, P; Maniar, S; Jiang, J; Fire, L; Patel, V; Hebert, A; Levit, M; Wang, A; Sun, F; Huang, SA Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors - Lead optimization - Part III. Bioorg Med Chem Lett 29:491-495 (2019) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50518505
Synonyms:
CHEMBL4518492
Type:
Small organic molecule
Emp. Form.:
C19H20Cl2N4O2
Mol. Mass.:
407.294
SMILES:
NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CCCO3)n([C@H]3CCCNC3)c2n1 |r|
Structure:
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