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Found 307 with Last Name = 'pribish' and Initial = 'j'
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518510(CHEMBL4448325)
Affinity DataKi:  0.100nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518517(CHEMBL4540910)
Affinity DataKi:  0.400nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518506(CHEMBL4588948)
Affinity DataKi:  0.600nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518520(CHEMBL4593810)
Affinity DataKi:  0.700nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518507(CHEMBL4583118)
Affinity DataKi:  0.900nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518518(CHEMBL4470576)
Affinity DataKi:  1.20nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518514(CHEMBL4563802)
Affinity DataKi:  1.20nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518505(CHEMBL4518492)
Affinity DataKi:  1.30nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156461(3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-...)
Affinity DataKi:  1.30nMAssay Description:Inhibitory activity against human mast cell tryptase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156460(3-[4-(3-Aminomethyl-phenyl)-piperidine-1-carbonyl]...)
Affinity DataKi:  1.5nMAssay Description:Inhibitory activity against human mast cell tryptase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518522(CHEMBL4466080)
Affinity DataKi:  3nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156457(CHEMBL186730 | [4-(5-Aminomethyl-2-fluoro-phenyl)-...)
Affinity DataKi:  4.30nMAssay Description:Inhibitory activity against human mast cell tryptase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167517(CHEMBL191546 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  32nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167534(CHEMBL370284 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  41nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167531(CHEMBL365527 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  41nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167524(CHEMBL192963 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  49nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167525(CHEMBL193514 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  57nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156459(3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-...)
Affinity DataKi:  59nMAssay Description:Inhibitory activity against human mast cell tryptase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167530(CHEMBL189101 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  61nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167514(CHEMBL370463 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  68nMAssay Description:Binding affinity of compound towards Factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156458(3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-...)
Affinity DataKi:  88nMAssay Description:Inhibitory activity against human mast cell tryptase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167520(CHEMBL365148 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  101nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167526(CHEMBL365189 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  116nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167522(CHEMBL372028 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  124nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167521(CHEMBL364661 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  125nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167511(CHEMBL189531 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  128nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM16127(2,2 -methanediylbis(1H-benzimidazole-6-carboximida...)
Affinity DataKi:  140nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167523(CHEMBL190103 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  141nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167535(CHEMBL191007 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  155nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167533(CHEMBL435694 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  162nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167510(CHEMBL361040 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  185nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167529(CHEMBL372912 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  197nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167515(1-{3-[4-(3-Aminomethyl-phenyl)-piperidine-1-carbon...)
Affinity DataKi:  240nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167513(CHEMBL192214 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  246nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167528(CHEMBL436537 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  290nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167519(CHEMBL190135 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  310nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167527(CHEMBL189983 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  368nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167518(CHEMBL189372 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  373nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167516(CHEMBL191731 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  497nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167532(CHEMBL191072 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi: >2.00E+4nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50167512(CHEMBL188104 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi: >2.00E+4nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561654(CHEMBL4785914)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in SFT accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561654(CHEMBL4785914)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in GalCer accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Mus musculus)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561654(CHEMBL4785914)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of mouse UGT8 assessed as redcution in GalCer accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Mus musculus)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561654(CHEMBL4785914)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of mouse UGT8 assessed as redcution in SFT accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561671(CHEMBL4796521)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in SFT accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561669(CHEMBL4787939)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in GalCer accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518510(CHEMBL4448325)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target2-hydroxyacylsphingosine 1-beta-galactosyltransferase(Homo sapiens)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50561671(CHEMBL4796521)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of UGT8 in human OE19 cells assessed as redcution in GalCer accumulation measured after 72 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50518521(CHEMBL4564586)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser-112 residue by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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