Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50344055
Substrate
n/a
Meas. Tech.
ChEMBL_1878371 (CHEMBL4379765)
Ki
>30000±n/a nM
Citation
 Matos, MJ; Vilar, S; Vazquez-Rodriguez, S; Kachler, S; Klotz, KN; Buccioni, M; Delogu, G; Santana, L; Uriarte, E; Borges, F Structure-Based Optimization of Coumarin hA J Med Chem 63:2577-2587 (2020) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50344055
Synonyms:
8-Ethoxy-3-phenylcoumarin | CHEMBL1777843
Type:
Small organic molecule
Emp. Form.:
C17H14O3
Mol. Mass.:
266.2913
SMILES:
CCOc1cccc2cc(-c3ccccc3)c(=O)oc12
Structure:
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