Reaction Details Report a problem with these data
Target
Endothelin-1 receptor
Ligand
BDBM50075424
Substrate
n/a
Meas. Tech.
ChEBML_63216
IC50
>10000±n/a nM
Citation
 Mederski, WW; Osswald, M; Dorsch, D; Christadler, M; Schmitges, CJ; Wilm, C Benzofuro[3,2-b]pyridines as mixed ET(A)/ET(B) and selective ET(B) endothelin receptor antagonists. Bioorg Med Chem Lett 9:619-22 (1999) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48256.91
Organism:
RAT
Description:
ENDOTHELIN A EDNRA RAT::P26684
Residue:
426
Sequence:
MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
  
Inhibitor
Name:
BDBM50075424
Synonyms:
7-Methanesulfonylamino-1-(2-methoxy-benzyl)-4-(4-methoxy-phenyl)-2-oxo-1,2-dihydro-benzo[4,5]furo[3,2-b]pyridine-3-carboxylic acid | CHEMBL156194
Type:
Small organic molecule
Emp. Form.:
C28H24N2O8S
Mol. Mass.:
548.564
SMILES:
COc1ccc(cc1)-c1c(C(O)=O)c(=O)n(Cc2ccccc2OC)c2c1oc1cc(NS(C)(=O)=O)ccc21
Structure:
Search PDB for entries with ligand similarity: