Reaction Details Report a problem with these data
Target
Proteasome assembly chaperone 3
Ligand
BDBM50520988
Substrate
n/a
Meas. Tech.
ChEMBL_1882721 (CHEMBL4384220)
IC50
20±n/a nM
Citation
 Ohsawa, K; Yoshida, M; Izumikawa, M; Takagi, M; Shin-Ya, K; Goshima, N; Hirokawa, T; Natsume, T; Doi, T Synthesis and biological evaluation of thielocin B1 analogues as protein-protein interaction inhibitors of PAC3 homodimer. Bioorg Med Chem 26:6023-6034 (2018) [PubMed]  Article 
Target
Name:
Proteasome assembly chaperone 3
Synonyms:
C7orf48 | PAC3 | PSMG3 | PSMG3_HUMAN
Type:
PROTEIN
Mol. Mass.:
13106.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_628263
Residue:
122
Sequence:
MEDTPLVISKQKTEVVCGVPTQVVCTAFSSHILVVVTQFGKMGTLVSLEPSSVASDVSKPVLTTKVLLGQDEPLIHVFAKNLVAFVSQEAGNRAVLLAVAVKDKSMEGLKALREVIRVCQVW
  
Inhibitor
Name:
BDBM50520988
Synonyms:
CHEMBL4435319
Type:
Small organic molecule
Emp. Form.:
C53H58O17
Mol. Mass.:
967.0174
SMILES:
COc1c(C)c(OC(=O)c2c(C)c(C)c(OC(=O)c3c(C)c(Oc4c(C)c(C)c(C(=O)Oc5c(C)c(C)c(C(O)=O)c(OC)c5C)c(OC)c4C)c(O)c(C)c3O)c(C)c2OC)c(C)c(C)c1C(O)=O
Structure:
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