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Target
Adenylate cyclase type 8
Ligand
BDBM50521067
Substrate
n/a
Meas. Tech.
ChEMBL_1883019 (CHEMBL4384518)
IC50
5600±n/a nM
Citation
 Kaur, J; Soto-Velasquez, M; Ding, Z; Ghanbarpour, A; Lill, MA; van Rijn, RM; Watts, VJ; Flaherty, DP Optimization of a 1,3,4-oxadiazole series for inhibition of Ca Eur J Med Chem 162:568-585 (2019) [PubMed]  Article 
Target
Name:
Adenylate cyclase type 8
Synonyms:
4.6.1.1 | AC8 | ADCY8 | ADCY8_HUMAN | ATP pyrophosphate-lyase 8 | Adenylate cyclase type 8 | Adenylate cyclase type VIII | Adenylyl cyclase 8 | Ca(2+)/calmodulin-activated adenylyl cyclase
Type:
PROTEIN
Mol. Mass.:
140131.08
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104878
Residue:
1251
Sequence:
MELSDVRCLTGSEELYTIHPTPPAGDGRSASRPQRLLWQTAVRHITEQRFIHGHRGGSGSGSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSASGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSGTEPGAQAEGTDKSDLP
  
Inhibitor
Name:
BDBM50521067
Synonyms:
CHEMBL4452051
Type:
Small organic molecule
Emp. Form.:
C23H16N4O3S
Mol. Mass.:
428.463
SMILES:
COc1ccc(cc1)-c1nnc(NC(=O)c2cc(nc3ccccc23)-c2cccs2)o1
Structure:
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