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Target
Nuclear receptor subfamily 4 group A member 1
Ligand
BDBM50481947
Substrate
n/a
Meas. Tech.
ChEMBL_1894490 (CHEMBL4396411)
Kd
960±n/a nM
Citation
 Chen, Z; Zhang, D; Yan, S; Hu, C; Huang, Z; Li, Z; Peng, S; Li, X; Zhu, Y; Yu, H; Lian, B; Kang, Q; Li, M; Zeng, Z; Zhang, XK; Su, Y SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway. Eur J Med Chem 177:171-187 (2019) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 4 group A member 1
Synonyms:
GFRP1 | HMR | NAK1 | NR4A1 | NR4A1_HUMAN | nuclear receptor subfamily 4, group A, member 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64467.13
Organism:
Homo sapiens (Human)
Description:
gi_27894344
Residue:
598
Sequence:
MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGYTGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF
  
Inhibitor
Name:
BDBM50481947
Synonyms:
CHEBI:8416 | GNF-Pf-476 | PRISTIMERIN | Pristimerine | US11660306, Example Pristimerin | acs.jmedchem.1c00409_ST.332
Type:
Small organic molecule
Emp. Form.:
C30H40O4
Mol. Mass.:
464.6362
SMILES:
[H][C@@]12C[C@@](C)(CC[C@]1(C)CC[C@]1(C)C3=CC=C4C(C)=C(O)C(=O)C=C4[C@]3(C)CC[C@@]21C)C(=O)OC |r,c:24,t:14,16,19|
Structure:
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