Reaction Details Report a problem with these data
Target
Phosphatidylcholine:ceramide cholinephosphotransferase 2
Ligand
BDBM50182491
Substrate
n/a
Meas. Tech.
ChEMBL_1897477 (CHEMBL4399512)
IC50
11000±n/a nM
Citation
 Othman, MA; Yuyama, K; Murai, Y; Igarashi, Y; Mikami, D; Sivasothy, Y; Awang, K; Monde, K Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice. ACS Med Chem Lett 10:1154-1158 (2019) [PubMed]  Article 
Target
Name:
Phosphatidylcholine:ceramide cholinephosphotransferase 2
Synonyms:
2.7.8.27 | Phosphatidylcholine:ceramide cholinephosphotransferase 2 | SMS2_MOUSE | Sgms2 | Sphingomyelin synthase 2
Type:
PROTEIN
Mol. Mass.:
42263.75
Organism:
Mus musculus
Description:
ChEMBL_119194
Residue:
365
Sequence:
MDIIETAKLEGHLESQTNDSTNTYTSPTEAVEEEGKNGKGKPKTLSNGLRKGAKKYPDYIQISMPNDSKNKFPLEWWKTGIAFVYALFNLILTTVMITVVHERVPPKELSPPLPDKFFDYFDRVKWAFSVSEINGMVLVGLWITQWLFLRYKSIVGRRFFFIMGTLYLYRCITMYVTTLPVPGMHFQCAPKLNGDSQAKIQRILRLISGGGLSITGSHILCGDFLFSGHTVVLTLTYLFIKEYSPRHFWWYHLVCWLLSAAGIICILVAHEHYTVDVIIAYYITTRLFWWYHSMANEKNLKVSSQTNFLSRAWWFPIFYFFEKNVQGSIPCCFSWPLSWPPGCFKSSCRKYSRVQKIGEDNEKST
  
Inhibitor
Name:
BDBM50182491
Synonyms:
CHEBI:69015 | Malabaricone C
Type:
Small organic molecule
Emp. Form.:
C21H26O5
Mol. Mass.:
358.4281
SMILES:
Oc1ccc(CCCCCCCCC(=O)c2c(O)cccc2O)cc1O
Structure:
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