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Target
Protein cereblon
Ligand
BDBM50526581
Substrate
n/a
Meas. Tech.
ChEMBL_1900220 (CHEMBL4402335)
Kd
10000±n/a nM
Citation
 Kargbo, RB PROTAC Molecules for the Treatment of Autoimmune Disorders. ACS Med Chem Lett 10:276-277 (2019) [PubMed]  Article 
Target
Name:
Protein cereblon
Synonyms:
CRBN | CRBN_HUMAN
Type:
PROTEIN
Mol. Mass.:
50537.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116917
Residue:
442
Sequence:
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
  
Inhibitor
Name:
BDBM50526581
Synonyms:
CHEMBL4466169 | US11459335, Compound 14 | US20230279023, Compound 14
Type:
Small organic molecule
Emp. Form.:
C15H19N3O3
Mol. Mass.:
289.3297
SMILES:
O=C1CCC(Nc2ccccc2N2CCOCC2)C(=O)N1
Structure:
Search PDB for entries with ligand similarity: