Reaction Details Report a problem with these data
Target
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Ligand
BDBM50526632
Substrate
n/a
Meas. Tech.
ChEMBL_1900510 (CHEMBL4402732)
IC50
24±n/a nM
Citation
 Patel, B; Ryan, P; Makwana, V; Zunk, M; Rudrawar, S; Grant, G Caprazamycins: Promising lead structures acting on a novel antibacterial target MraY. Eur J Med Chem 171:462-474 (2019) [PubMed]  Article 
Target
Name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Synonyms:
MRAY_STAAU | mraY
Type:
PROTEIN
Mol. Mass.:
35238.55
Organism:
Staphylococcus aureus (strain MRSA252)
Description:
ChEMBL_827497
Residue:
321
Sequence:
MIFVYALLALVITFVLVPVLIPTLKRMKFGQSIREEGPQSHMKKTGTPTMGGLTFLLSIVITSLVAIIFVDQANPIILLLFVTIGFGLIGFIDDYIIVVKKNNQGLTSKQKFLAQIGIAIIFFVLSNVFHLVNFSTSIHIPFTNVAIPLSFAYVIFIVFWQVGFSNAVNLTDGLDGLATGLSIIGFTMYAIMSFVLGETAIGIFCIIMLFALLGFLPYNINPAKVFMGDTGSLALGGIFATISIMLNQELSLIFIGLVFVIETLSVMLQVASFKLTGKRIFKMSPIHHHFELIGWSEWKVVTVFWAVGLISGLIGLWIGVH
  
Inhibitor
Name:
BDBM50526632
Synonyms:
CHEMBL4473600
Type:
Small organic molecule
Emp. Form.:
C35H61N5O10
Mol. Mass.:
711.8863
SMILES:
[H][C@@]1(O[C@H]([C@@]2([H])O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@]2([H])C[C@H](CCN2)NC(=O)CCCCCCCCCCCCCCC)O[C@H](CN)[C@@H](O)[C@H]1O |r|
Structure:
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