Reaction Details Report a problem with these data
Target
Genome polyprotein
Ligand
BDBM50081845
Substrate
n/a
Meas. Tech.
ChEMBL_158961 (CHEMBL769697)
IC50
2680±n/a nM
Citation
 Ertl, P; Cooper, D; Allen, G; Slater, MJ 2-chloro-3-substituted-1,4-naphthoquinone inactivators of human cytomegalovirus protease. Bioorg Med Chem Lett 9:2863-6 (1999) [PubMed]  Article 
Target
Name:
Genome polyprotein
Synonyms:
Human rhinovirus A protease | Human rhinovirus B 3A protease
Type:
PROTEIN
Mol. Mass.:
44361.04
Organism:
Human rhinovirus B
Description:
ChEMBL_158953
Residue:
401
Sequence:
AFRPCNVNTKIGNAKCCPFVCGKAVTFKDRSTCSTYNLSSSLHHILEEDKRRRQVVDVMSAIFQGPISLDAPPPPAIADLLQSVRTPRVIKYCQIIMGHPAECQVERDLNIANSIIAIIANIISIAGIIFVIYKLFCSLQGPYSGEPKPKTKVPERRVVAQGPEEEFGRSILKNNTCVITTGNGKFTGLGIHDRILIIPTHADPGREVQVNGVHTKVLDSYDLYNRDGVKLEITVIQLDRNEKFRDIRKYIPETEDDYPECNLALSANQDEPTIIKVGDVVSYGNILLSGNQTARMLKYNYPTKSGYCGGVLYKIGQILGIHVGGNGRDGFSAMLLRSYFTGQIKVNKHATECGLPDIQTIHTPSKTKLQPSVFYDVFPGSKEPAVLTDNDPRLEVNFKEA
  
Inhibitor
Name:
BDBM50081845
Synonyms:
2-(3-Chloro-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-3-oxo-butyric acid isopropyl ester | CHEMBL95798
Type:
Small organic molecule
Emp. Form.:
C17H15ClO5
Mol. Mass.:
334.751
SMILES:
CC(C)OC(=O)C(C(C)=O)C1=C(Cl)C(=O)c2ccccc2C1=O |c:10|
Structure:
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