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Target
L-lactate dehydrogenase B chain
Ligand
BDBM50527811
Substrate
n/a
Meas. Tech.
ChEMBL_1903682 (CHEMBL4405904)
Kd
465000±n/a nM
Citation
 Thabault, L; Brisson, L; Brustenga, C; Martinez Gache, SA; Prévost, JRC; Kozlova, A; Spillier, Q; Liberelle, M; Benyahia, Z; Messens, J; Copetti, T; Sonveaux, P; Frédérick, R Interrogating the Lactate Dehydrogenase Tetramerization Site Using (Stapled) Peptides. J Med Chem 63:4628-4643 (2020) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase B chain
Synonyms:
L-lactate dehydrogenase B | L-lactate dehydrogenase B chain | LDH heart subunit | LDH-B | LDH-H | LDHB | LDHB_HUMAN | Lactate dehydrogenase B (LDHB) | Renal carcinoma antigen NY-REN-46
Type:
Oxidoreductase; homotetramer
Mol. Mass.:
36635.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
334
Sequence:
MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
  
Inhibitor
Name:
BDBM50527811
Synonyms:
CHEMBL4450669
Type:
Small organic molecule
Emp. Form.:
C42H77N11O10
Mol. Mass.:
896.1285
SMILES:
[H][C@]1(NC(=O)[C@H](C)NC(=O)CC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O)[C@@H](C)O |r|
Structure:
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