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Target
Cysteine protease ATG4B
Ligand
BDBM50528267
Substrate
n/a
Meas. Tech.
ChEMBL_1904757 (CHEMBL4407115)
IC50
360±n/a nM
Citation
 Quintana, M; Bilbao, A; Comas-Barceló, J; Bujons, J; Triola, G Identification of benzo[cd]indol-2(1H)-ones as novel Atg4B inhibitors via a structure-based virtual screening and a novel AlphaScreen assay. Eur J Med Chem 178:648-666 (2019) [PubMed]  Article 
Target
Name:
Cysteine protease ATG4B
Synonyms:
APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44279.79
Organism:
Homo sapiens (Human)
Description:
gi_47132611
Residue:
393
Sequence:
MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
  
Inhibitor
Name:
BDBM50528267
Synonyms:
CHEMBL4469737
Type:
Small organic molecule
Emp. Form.:
C24H23FN2O4
Mol. Mass.:
422.4488
SMILES:
FCC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1cccc2ccccc12 |r|
Structure:
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