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Target
Interstitial collagenase
Ligand
BDBM50084742
Substrate
n/a
Meas. Tech.
ChEMBL_105955 (CHEMBL715368)
IC50
322±n/a nM
Citation
 Cheng, M; De, B; Pikul, S; Almstead, NG; Natchus, MG; Anastasio, MV; McPhail, SJ; Snider, CE; Taiwo, YO; Chen, L; Dunaway, CM; Gu, F; Dowty, ME; Mieling, GE; Janusz, MJ; Wang-Weigand, S Design and synthesis of piperazine-based matrix metalloproteinase inhibitors. J Med Chem 43:369-80 (2000) [PubMed]  Article 
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
  
Inhibitor
Name:
BDBM50084742
Synonyms:
4-(4-Methoxy-benzenesulfonyl)-piperazine-1,3-dicarboxylic acid 1-(benzyl-methyl-amide) 3-hydroxyamide | CHEMBL126004
Type:
Small organic molecule
Emp. Form.:
C21H26N4O6S
Mol. Mass.:
462.519
SMILES:
COc1ccc(cc1)S(=O)(=O)N1CCN(CC1C(=O)NO)C(=O)N(C)Cc1ccccc1
Structure:
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