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Target
Bifunctional epoxide hydrolase 2
Ligand
BDBM50530480
Substrate
n/a
Meas. Tech.
ChEMBL_1912691 (CHEMBL4415274)
IC50
>30000±n/a nM
Citation
 Kramer, JS; Woltersdorf, S; Duflot, T; Hiesinger, K; Lillich, FF; Knöll, F; Wittmann, SK; Klingler, FM; Brunst, S; Chaikuad, A; Morisseau, C; Hammock, BD; Buccellati, C; Sala, A; Rovati, GE; Leuillier, M; Fraineau, S; Rondeaux, J; Hernandez-Olmos, V; Heering, J; Merk, D; Pogoryelov, D; Steinhilber, D; Knapp, S; Bellien, J; Proschak, E Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain. J Med Chem 62:8443-8460 (2019) [PubMed]  Article 
Target
Name:
Bifunctional epoxide hydrolase 2
Synonyms:
Eph2 | Ephx2 | Epoxide hydratase | HYES_MOUSE | Soluble epoxide hydrolase (sEH)
Type:
Enzyme
Mol. Mass.:
62512.06
Organism:
Mus musculus (Mouse)
Description:
P34914
Residue:
554
Sequence:
MALRVAAFDLDGVLALPSIAGAFRRSEEALALPRDFLLGAYQTEFPEGPTEQLMKGKITFSQWVPLMDESYRKSSKACGANLPENFSISQIFSQAMAARSINRPMLQAAIALKKKGFTTCIVTNNWLDDGDKRDSLAQMMCELSQHFDFLIESCQVGMIKPEPQIYNFLLDTLKAKPNEVVFLDDFGSNLKPARDMGMVTILVHNTASALRELEKVTGTQFPEAPLPVPCNPNDVSHGYVTVKPGIRLHFVEMGSGPALCLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSPPEIEEYAMELLCKEMVTFLDKLGIPQAVFIGHDWAGVMVWNMALFYPERVRAVASLNTPFMPPDPDVSPMKVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRASDETGFIAVHKATEIGGILVNTPEDPNLSKITTEEEIEFYIQQFKKTGFRGPLNWYRNTERNWKWSCKGLGRKILVPALMVTAEKDIVLRPEMSKNMEKWIPFLKRGHIEDCGHWTQIEKPTEVNQILIKWLQTEVQNPSVTSKI
  
Inhibitor
Name:
BDBM50530480
Synonyms:
CHEMBL4445524
Type:
Small organic molecule
Emp. Form.:
C19H15Cl2NO3
Mol. Mass.:
376.233
SMILES:
OC(=O)CCCc1nc(c(o1)-c1ccccc1)-c1ccc(Cl)c(Cl)c1
Structure:
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