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Target
Serine--tRNA ligase, cytoplasmic
Ligand
BDBM50530861
Substrate
n/a
Meas. Tech.
ChEMBL_1914053 (CHEMBL4416636)
IC50
>1000000±n/a nM
Citation
 Cain, R; Salimraj, R; Punekar, AS; Bellini, D; Fishwick, CWG; Czaplewski, L; Scott, DJ; Harris, G; Dowson, CG; Lloyd, AJ; Roper, DI Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase. J Med Chem 62:9703-9717 (2019) [PubMed]  Article 
Target
Name:
Serine--tRNA ligase, cytoplasmic
Synonyms:
6.1.1.11 | SARS | SARS1 | SERS | SYSC_HUMAN | SerRS | Serine--tRNA ligase, cytoplasmic | Seryl-tRNA synthetase | Seryl-tRNA(Ser/Sec) synthetase
Type:
PROTEIN
Mol. Mass.:
58775.58
Organism:
Homo sapiens
Description:
ChEMBL_118982
Residue:
514
Sequence:
MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCSKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKPAPIEQEPSKKQKKQHEGSKKKAAARDVTLENRLQNMEVTDA
  
Inhibitor
Name:
BDBM50530861
Synonyms:
CHEMBL4452350
Type:
Small organic molecule
Emp. Form.:
C16H23N7O8S
Mol. Mass.:
473.461
SMILES:
C\C=C\c1nc(N)c2ncn([C@@H]3O[C@H](COS(=O)(=O)NC(=O)[C@@H](N)CO)[C@@H](O)[C@H]3O)c2n1 |r|
Structure:
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