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Target
Atrial natriuretic peptide receptor 1
Ligand
BDBM50091755
Substrate
n/a
Meas. Tech.
ChEBML_34995
Ki
539±n/a nM
Citation
 Veale, CA; Alford, VC; Aharony, D; Banville, DL; Bialecki, RA; Brown, FJ; Damewood, JR; Dantzman, CL; Edwards, PD; Jacobs, RT; Mauger, RC; Murphy, MM; Palmer, W; Pine, KK; Rumsey, WL; Garcia-Davenport, LE; Shaw, A; Steelman, GB; Surian, JM; Vacek, EP The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg Med Chem Lett 10:1949-52 (2001) [PubMed]  Article 
Target
Name:
Atrial natriuretic peptide receptor 1
Synonyms:
ANP-A | ANPRA | ANPRA_HUMAN | Atrial natriuretic peptide A-type receptor | Atrial natriuretic peptide receptor | Atrial natriuretic peptide receptor A | GC-A | Guanylate cyclase | NPR-A | NPR1
Type:
PROTEIN
Mol. Mass.:
118919.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_700223
Residue:
1061
Sequence:
MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG
  
Inhibitor
Name:
BDBM50091755
Synonyms:
(S)-N-[(S)-4-Guanidino-1-((S)-2-methyl-pentylcarbamoyl)-butyl]-3-[(2S,3S)-2-((S)-5-guanidino-2-phenylacetylamino-pentanoylamino)-3-methyl-pentanoylamino]-succinamic acid | CHEMBL435181
Type:
Small organic molecule
Emp. Form.:
C36H61N11O7
Mol. Mass.:
759.939
SMILES:
CCC[C@H](C)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)Cc1ccccc1)[C@@H](C)CC
Structure:
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