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Target
Hydroxycarboxylic acid receptor 1
Ligand
BDBM50539695
Substrate
n/a
Meas. Tech.
ChEMBL_1978551 (CHEMBL4611686)
EC50
160±n/a nM
Citation
 Davidsson, Ö; Nilsson, K; Brånalt, J; Andersson, T; Berggren, K; Chen, Y; Fjellström, O; Gradén, H; Gustafsson, L; Hermansson, NO; Jansen, F; Johannesson, P; Ohlsson, B; Tyrchan, C; Wellner, A; Wellner, E; Ölwegård-Halvarsson, M Identification of novel GPR81 agonist lead series for target biology evaluation. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 1
Synonyms:
G-protein coupled receptor 104 | GPR104 | GPR81 | HCA1 | HCAR1 | HCAR1_HUMAN
Type:
PROTEIN
Mol. Mass.:
39313.04
Organism:
Homo sapiens (Human)
Description:
ChEMBL_850283
Residue:
346
Sequence:
MYNGSCCRIEGDTISQVMPPLLIVAFVLGALGNGVALCGFCFHMKTWKPSTVYLFNLAVADFLLMICLPFRTDYYLRRRHWAFGDIPCRVGLFTLAMNRAGSIVFLTVVAADRYFKVVHPHHAVNTISTRVAAGIVCTLWALVILGTVYLLLENHLCVQETAVSCESFIMESANGWHDIMFQLEFFMPLGIILFCSFKIVWSLRRRQQLARQARMKKATRFIMVVAIVFITCYLPSVSARLYFLWTVPSSACDPSVHGALHITLSFTYMNSMLDPLVYYFSSPSFPKFYNKLKICSLKPKQPGHSKTQRPEEMPISNLGRRSCISVANSFQSQSDGQWDPHIVEWH
  
Inhibitor
Name:
BDBM50539695
Synonyms:
CHEMBL4649741
Type:
Small organic molecule
Emp. Form.:
C29H38ClN5O5S2
Mol. Mass.:
636.226
SMILES:
CCOc1cc(Cl)c(cc1N1CCO[C@H](C)C1)C(=O)Nc1nc2ccc(cc2s1)S(=O)(=O)CCCN1CCN(C)CC1 |r|
Structure:
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