Reaction Details Report a problem with these data
Target
Retinoic acid receptor RXR-alpha
Ligand
BDBM50301375
Substrate
n/a
Meas. Tech.
ChEMBL_1995681 (CHEMBL4629576)
EC50
15400±n/a nM
Citation
Gellrich, L; Heitel, P; Heering, J; Kilu, W; Pollinger, J; Goebel, T; Kahnt, A; Arifi, S; Pogoda, W; Paulke, A; Steinhilber, D; Proschak, E; Wurglics, M; Schubert-Zsilavecz, M; Chaikuad, A; Knapp, S; Bischoff, I; Fürst, R; Merk, D l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPAR?. J Med Chem 63:6727-6740 (2020) [PubMed] Article
More Info.:
Target
Name:
Retinoic acid receptor RXR-alpha
Synonyms:
NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50820.38
Organism:
Human
Description:
ChEMBL_1456363
Residue:
462
Sequence:
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
Inhibitor
Name:
BDBM50301375
Synonyms:
3,3',5,5'-tetraiodo-L-thyronine | 3,5,3',5'-tetraiodo-L-thyronine | 4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine | CHEMBL1624 | L-T4 | L-thyroxine | O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine | levothyroxine
Type:
Small organic molecule
Emp. Form.:
C15H11I4NO4
Mol. Mass.:
776.87
SMILES:
N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O |r|