Reaction Details Report a problem with these data
Target
Sialin
Ligand
BDBM115093
Substrate
n/a
Meas. Tech.
ChEMBL_1996365 (CHEMBL4630260)
IC50
23300±n/a nM
Citation
Dubois, L; Pietrancosta, N; Cabaye, A; Fanget, I; Debacker, C; Gilormini, PA; Dansette, PM; Dairou, J; Biot, C; Froissart, R; Goupil-Lamy, A; Bertrand, HO; Acher, FC; McCort-Tranchepain, I; Gasnier, B; Anne, C Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin. J Med Chem 63:8231-8249 (2020) [PubMed] Article
More Info.:
Target
Name:
Sialin
Synonyms:
AST | H(+)/nitrate cotransporter | H(+)/sialic acid cotransporter | Membrane glycoprotein HP59 | S17A5_HUMAN | SLC17A5 | Sialin | Solute carrier family 17 member 5 | Vesicular H(+)/Aspartate-glutamate cotransporter
Type:
PROTEIN
Mol. Mass.:
54648.96
Organism:
Homo sapiens
Description:
ChEMBL_119952
Residue:
495
Sequence:
MRSPVRDLARNDGEESTDRTPLLPGAPRAEAAPVCCSARYNLAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSLRNQLSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFAKGEVQNWALNDHHGHRH
Inhibitor
Name:
BDBM115093
Synonyms:
(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoic acid | (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methyl-valeric acid | (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylpentanoic acid | (2S)-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-4-methylpentanoic acid | Fmoc-L-leucine | MLS002695993 | SMR001562137 | cid_1549133
Type:
Small organic molecule
Emp. Form.:
C21H23NO4
Mol. Mass.:
353.4116
SMILES:
CC(C)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(O)=O