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Target
Sialin
Ligand
BDBM50545752
Substrate
n/a
Meas. Tech.
ChEMBL_1996380 (CHEMBL4630275)
Ki
7800±n/a nM
Citation
 Dubois, L; Pietrancosta, N; Cabaye, A; Fanget, I; Debacker, C; Gilormini, PA; Dansette, PM; Dairou, J; Biot, C; Froissart, R; Goupil-Lamy, A; Bertrand, HO; Acher, FC; McCort-Tranchepain, I; Gasnier, B; Anne, C Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin. J Med Chem 63:8231-8249 (2020) [PubMed]  Article 
Target
Name:
Sialin
Synonyms:
AST | H(+)/nitrate cotransporter | H(+)/sialic acid cotransporter | Membrane glycoprotein HP59 | S17A5_HUMAN | SLC17A5 | Sialin | Solute carrier family 17 member 5 | Vesicular H(+)/Aspartate-glutamate cotransporter
Type:
PROTEIN
Mol. Mass.:
54648.96
Organism:
Homo sapiens
Description:
ChEMBL_119952
Residue:
495
Sequence:
MRSPVRDLARNDGEESTDRTPLLPGAPRAEAAPVCCSARYNLAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSLRNQLSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFAKGEVQNWALNDHHGHRH
  
Inhibitor
Name:
BDBM50545752
Synonyms:
CHEMBL4646356
Type:
Small organic molecule
Emp. Form.:
C28H23NO7S
Mol. Mass.:
517.55
SMILES:
OC(=O)[C@H](CSCc1cc(=O)oc2cc(O)ccc12)NC(=O)OCC1c2ccccc2-c2ccccc12 |r|
Structure:
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