Reaction Details Report a problem with these data
Target
Thrombopoietin receptor
Ligand
BDBM50105936
Substrate
n/a
Meas. Tech.
ChEMBL_207477 (CHEMBL815867)
EC50
2000±n/a nM
Citation
Duffy, KJ; Darcy, MG; Delorme, E; Dillon, SB; Eppley, DF; Erickson-Miller, C; Giampa, L; Hopson, CB; Huang, Y; Keenan, RM; Lamb, P; Leong, L; Liu, N; Miller, SG; Price, AT; Rosen, J; Shah, R; Shaw, TN; Smith, H; Stark, KC; Tian, SS; Tyree, C; Wiggall, KJ; Zhang, L; Luengo, JI Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis. J Med Chem 44:3730-45 (2001) [PubMed] Article
More Info.:
Target
Name:
Thrombopoietin receptor
Synonyms:
C-mpl | CD_antigen=CD110 | MPL | Myeloproliferative leukemia protein | TPO-R | TPOR | TPOR_HUMAN
Type:
PROTEIN
Mol. Mass.:
71243.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_535587
Residue:
635
Sequence:
MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
Inhibitor
Name:
BDBM50105936
Synonyms:
3-Hydroxy-4-[N'-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-pyrazol-4-ylidene)-hydrazino]-naphthalene-1-sulfonic acid | CHEMBL122211
Type:
Small organic molecule
Emp. Form.:
C20H16N4O5S
Mol. Mass.:
424.43
SMILES:
Cc1[nH]n(-c2ccccc2)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O |w:14.16|