Reaction Details Report a problem with these data
Target
Arginase-1
Ligand
BDBM50547934
Substrate
n/a
Meas. Tech.
ChEMBL_2019398 (CHEMBL4672976)
IC50
18±n/a nM
Citation
 Sabnis, RW Novel Arginase Inhibitors for Treating Cancer and Respiratory Inflammatory Diseases. ACS Med Chem Lett 11:2370-2371 (2020) [PubMed]  Article 
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM50547934
Synonyms:
CHEMBL4757930
Type:
Small organic molecule
Emp. Form.:
C16H32BN3O5
Mol. Mass.:
357.253
SMILES:
CC(C)C[C@H](N)C(=O)N[C@H]1CCN[C@](CCCCB(O)O)(C1)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: