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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50110577
Substrate
n/a
Meas. Tech.
ChEMBL_226364 (CHEMBL847532)
Ki
0.4±n/a nM
Citation
 Emond, P; Vercouillie, J; Innis, R; Chalon, S; Mavel, S; Frangin, Y; Halldin, C; Besnard, JC; Guilloteau, D Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation. J Med Chem 45:1253-8 (2002) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor
Type:
Multi-pass membrane protein
Mol. Mass.:
70168.43
Organism:
Rattus norvegicus (rat)
Description:
P31652
Residue:
630
Sequence:
METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
  
Inhibitor
Name:
BDBM50110577
Synonyms:
2-(2-((dimethylamino)methyl)phenylthio)-5-iodoaniline | 2-(2-Dimethylaminomethyl-phenylsulfanyl)-5-iodo-phenylamine | CHEMBL23034 | CHEMBL2314218
Type:
Small organic molecule
Emp. Form.:
C15H17IN2S
Mol. Mass.:
384.278
SMILES:
CN(C)Cc1ccccc1Sc1ccc(I)cc1N
Structure:
Search PDB for entries with ligand similarity: