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Target
Prostaglandin G/H synthase 2
Ligand
BDBM50111221
Substrate
n/a
Meas. Tech.
ChEBML_157994
IC50
100±n/a nM
Citation
 Noguchi, T; Shimazawa, R; Nagasawa, K; Hashimoto, Y Thalidomide and its analogues as cyclooxygenase inhibitors. Bioorg Med Chem Lett 12:1043-6 (2002) [PubMed]  Article 
Target
Name:
Prostaglandin G/H synthase 2
Synonyms:
COX2 | Cyclooxygenase-1 (COX-1) | Cyclooxygenase-2 (COX-2) | PGH2_SHEEP | PTGS2 | Prostaglandin G/H synthase (Cyclooxygenase-2) | Prostaglandin G/H synthase (cyclooxygenase)
Type:
Protein
Mol. Mass.:
68976.98
Organism:
Ovis aries (Sheep)
Description:
n/a
Residue:
603
Sequence:
MLARALLLCAAVVCGAANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCTTPEFLTRIKLLLKPTPDTVHYILTHFKGVWNIVNKISFLRNMIMRYVLTSRSHLIESPPTYNVHYSYKSWEAFSNLSYYTRALPPVPDDCPTPMGVKGRKELPDSKEVVKKVLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTDIERGPAFTKGKNHGVDLSHVYGESLERQHNRRLFKDGKMKYQMINGEMYPPTVKDTQVEMIYPPHIPEHLKFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIAAEFNTLYHWHPLLPDVFQIDGQEYNYQQFIYNNSVLLEHGVTQFVESFTRQIAGRVAGRRNLPAAVEKVSKASLDQSREMKYQSFNEYRKRFLLKPYESFEELTGEKEMAAELEALYGDIDAMELYPALLVEKPAPDAIFGETMVEAGAPFSLKGLMGNPICSPEYWKPSTFGGEVGFKIINTASIQSLICSNVKGCPFTSFSVQDAHLTKTVTINASSSHSGLDDINPTVLLKERSTEL
  
Inhibitor
Name:
BDBM50111221
Synonyms:
2-((R)-3-Methyl-2,6-dioxo-piperidin-3-yl)-4-nitro-isoindole-1,3-dione | CHEMBL9191
Type:
Small organic molecule
Emp. Form.:
C14H11N3O6
Mol. Mass.:
317.2536
SMILES:
C[C@]1(CCC(=O)NC1=O)N1C(=O)c2cccc(c2C1=O)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: