Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50114829
Substrate
n/a
Meas. Tech.
ChEMBL_87852 (CHEMBL701992)
IC50
6±n/a nM
Citation
Woo, SH; Frechette, S; Abou Khalil, E; Bouchain, G; Vaisburg, A; Bernstein, N; Moradei, O; Leit, S; Allan, M; Fournel, M; Trachy-Bourget, MC; Li, Z; Besterman, JM; Delorme, D Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors. J Med Chem 45:2877-85 (2002) [PubMed] Article
More Info.:
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
Inhibitor
Name:
BDBM50114829
Synonyms:
(E)-8-Naphthalen-2-yl-oct-7-enoic acid hydroxyamide | 8-Naphthalen-2-yl-oct-7-enoic acid hydroxyamide | CHEMBL451182 | N-hydroxy-8-(naphthalen-2-yl)oct-7-enamide
Type:
Small organic molecule
Emp. Form.:
C18H21NO2
Mol. Mass.:
283.3648
SMILES:
ONC(=O)CCCCC\C=C\c1ccc2ccccc2c1