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Target
Probable G-protein coupled receptor 88
Ligand
BDBM50555041
Substrate
n/a
Meas. Tech.
ChEMBL_2051139 (CHEMBL4705838)
EC50
71±n/a nM
Citation
 Rahman, MT; Decker, AM; Langston, TL; Mathews, KM; Laudermilk, L; Maitra, R; Ma, W; Darcq, E; Kieffer, BL; Jin, C Design, Synthesis, and Structure-Activity Relationship Studies of (4-Alkoxyphenyl)glycinamides and Bioisosteric 1,3,4-Oxadiazoles as GPR88 Agonists. J Med Chem 63:14989-15012 (2020) [PubMed]  Article 
Target
Name:
Probable G-protein coupled receptor 88
Synonyms:
GPR88 | GPR88_HUMAN | Probable G-protein coupled receptor 88 | STRG | Striatum-specific G-protein coupled receptor
Type:
PROTEIN
Mol. Mass.:
40264.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109566
Residue:
384
Sequence:
MTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
  
Inhibitor
Name:
BDBM50555041
Synonyms:
CHEMBL4751633
Type:
Small organic molecule
Emp. Form.:
C24H31ClN4O3
Mol. Mass.:
458.981
SMILES:
Cl.CC[C@H](C)COc1ccc(cc1)[C@H](Cc1nnc(N)o1)NC(=O)[C@@H](C)c1ccccc1 |r|
Structure:
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